中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (11): 655-658.doi: 10.12144/zgmfskin201911655

• 论著 • 上一篇    下一篇

SGK1在日光性角化病、基底细胞癌及鳞状细胞癌中的表达

孟琴琴1  郭美亮1  范晴2  袁定芬1  邓辉1   

  1. 1上海交通大学附属第六人民医院，上海，200233
    2上海交通大学附属第六人民医院南院（上海市奉贤区中心医院）,201400
  • 出版日期:2019-11-15 发布日期:2019-11-20
  • 通讯作者: 邓辉，E-mail：hdeng@sjtu.edu.cn

Expression of SGK1 in actinic keratosis, basal cell carcinoma and squamous cell carcinoma

MENG Qinqin1，GUO Meiliang1，FAN Qing2，YUAN Dingfen1，DENG Hui1   

  1. 1. Department of Dermatology， Shanghai Jiao Tong University Affiliated Sixth People's Hospital，Shanghai 200233，China；2. Department of Dermatology，Shanghai Jiao Tong University Affiliated Sixth People's Hospital，South Campus，Shanghai 201400，China
  • Online:2019-11-15 Published:2019-11-20
  • Contact: DENG Hui，E-mail：hdeng@sjtu.edu.cn

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摘要： 目的：检测SGK1在日光性角化病（AK）、基底细胞癌（BCC）及鳞状细胞癌（SCC）中的表达。方法：采用免疫组化SABC法检测SGK1在25例正常皮肤(NS)、25例AK、28例BCC、28例皮肤鳞状细胞癌标本中的表达。结果：NS、AK、BCC和SCC标本中，SGK1阳性细胞率分别为（40.03±14.42）%，（36.63±14.28）%，（52.82±18.73）%和（52.58±20.13）%。BCC组和SCC组分别与NS组比较，差异均有统计学意义（Ps<0.05）。各组SGK1染色阳性细胞率>50%的标本分别为6例（24%），3例（12%），16例（57.14%）和14例（50%）,BCC组和SCC组分别与NS组比较，差异均有统计学意义（Ps<0.05）。结论：SGK1的高表达可能与基底细胞癌及鳞状细胞癌的发病有关。

关键词: 日光性角化病, 基底细胞癌, 鳞状细胞癌, SGK1

Abstract: Objective: To detect the expression of SGK1 in the lesions of actinic keratosis (AK)，basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Methods: The expression levels of SGK1 were detected by immunohistochemical SABC method in the samples of 25 normal skin (NS), 25 AK, 28 BCC and 28 SCC. Results: In the samples of NS, AK, BCC and SCC，the positivity rates of SGK1 cells were (40.03±14.42)%, (36.63±14.28)%, (52.82±18.73)% and (52.58±20.13)% respectively, and there were significant differences in positivity rates between BCC, SCC group and NS group (Ps<0.05). The cells positivity rate >50% were seen in 6 NS samples (24%), 3 AK (12%)，16 BCC (57.14%) and 14 SCC (50%). The positivity rates were significant differences between BCC, SCC group and NS group (Ps<0.05). Conclusion: SGK1 may play a role in the pathogenesis of basal cell carcinoma and squamous cell carcinoma.

Key words: actinic keratosis, basal cell carcinoma, squamous cell carcinoma, SGK1