中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (9): 513-516.

• 论著 •    下一篇

GPR78与ETS1基因交互作用与系统性红斑狼疮的相关性研究

后俊生1  张学军2,3,4   

  1. 1南京市溧水区人民医院皮肤科，江苏南京，211200
    2安徽医科大学第一附属医院皮肤科，安徽合肥，230032
    3安徽医科大学皮肤病研究所，安徽合肥，230032
    4皮肤病学教育部重点实验室，安徽合肥，230032
  • 出版日期:2017-09-15 发布日期:2018-12-05
  • 通讯作者: 张学军，E-mail：ayzxj@vip.sina.com

Interactions between GPR78 and ETS1 gene associate with systemic lupus erythematosus

HOU Junsheng1, ZHANG Xuejun2,3,4.   

  1. 1. Department of Dermatology, Nanjing Lishui People's Hospital, Nanjing 211200, China; 
    2. Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; 
    3. Institute of Dermatology, Anhui Medical University, Hefei 230032, China; 
    4. Key Laboratory of Dermatology, Ministry of Education, Hefei 230032, China
  • Online:2017-09-15 Published:2018-12-05
  • Contact: ZHANG Xuejun, E-mail: ayzxj@vip.sina.com

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摘要：

目的：明确GPR78和ETS1基因的交互作用对系统性红斑狼疮(SLE)发病的影响。方法：在前期GWAS的基础上，选择可能存在共同生物学效应的GPR78（SNP rs3103074）和ETS1（SNP rs6590330），在中国汉族人群4199例SLE和8255名对照中基因分型。通过logistic回归模式检验这两者之间可能存在的交互作用。结果：GPR78和ETS1基因在中国汉族人SLE发病中存在显著的交互作用(Pcombined=1.4×10-4,OR=1.27)。单个SNP与SLE的关联性分析发现GPR78（SNP rs3103074）是提示点(P=6.2×10-4,OR=1.22,95% CI:1.12~1.32)，与SLE中度关联。结论：GPR78与ETS1基因之间存在着显著的交互作用，可能在SLE的发病中发挥作用。

关键词: 系统性红斑狼疮, ETS1, GPR78, 交互作用

Abstract:

Objective: To determine the potential effects of the interaction of GPR78 (rs3103074) and ETS1 (rs6590330) on systemic lupus erythematosus (SLE). Methods: Based on our previous GWAS of SLE, GPR78 (SNP rs3103074) and ETS1 (SNP rs6590330) (maybe have an interaction in the pathogenesis of SLE) were chosen. In total, 4199 patients and 8255 controls from Chinese Han population were genotyped for GPR78 rs3103074 and ETS1 rs6590330. Pair-wise interactions between SNPs were evaluated from likelihood ratio tests utilizing logistic regression models. Results: A significant interactive effect between GPR78 rs3103074 and ETS1 rs6590330 on SLE susceptibility (Pcombined=1.4×10-4,OR=1.27) was found through logistic regression analysis. GPR78 rs3103074 was suggestive of SNP, showed medium association with SLE (Pcombined=6.2×10-4,OR=1.22, 95% CI:1.12-1.32) through single SNP association analyses. Conclusion: There is a significant interaction between gene GPR78 and ETS1, which may play a role in the pathogenesis of SLE.

Key words: SLE, ETS1, GPR78, interaction