中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (9): 567-571.

• 综述 • 上一篇    下一篇

CARD9在感染性疾病中的研究进展

曹静1,2  张福仁1,2   

  1. 1山东大学附属省皮肤病医院，山东大学，济南，250022
    2山东省皮肤病性病防治研究所，山东省医学科学院，济南，250022
  • 出版日期:2017-09-15 发布日期:2018-12-06
  • 通讯作者: 张福仁，E-mail: zhangfuren@hotmail.com

Update of caspase recruitment domain containing protein 9 in infectious diseases

CAO Jing1,2, ZHANG Furen1,2.   

  1. 1. Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan 250022, China; 2. Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2017-09-15 Published:2018-12-06
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 胱天蛋白酶募集域蛋白9（CARD9）是CARD蛋白家族中的一员，是重要的衔接蛋白，通过蛋白-蛋白相互作用调节细胞内信号传递。CARD9能高效整合多种固有免疫受体的识别信号，在机体对真菌、细菌、病毒等的识别和抵抗方面起重要作用。近年来有多例因CARD9缺陷导致的深部真菌病和泛发性复发性皮肤黏膜真菌感染的病例报道，使得CARD9在感染性疾病中的研究日益受到关注。本文就CARD9在感染性疾病中的分子调控机制进行了综述。

关键词: 胱天蛋白酶募集域蛋白, 感染性疾病, 固有免疫, 信号通路

Abstract: Caspase recruitment domain-containing protein 9 (CARD9) is a member of the CARD protein family, which is a nonredundant adapter protein regulating intra-cellular signal transduction pathway through CARD-CARD interaction. CARD9 is a key signaling molecule for innate immune responses, which plays an important role in recognizing and resisting the fungi and bacteria infection. CARD9 deficiency has been reported to be associated with severe fungal diseases and chronic mucocutaneous candidiasis. The potential molecular mechanism of CARD9 in infectious diseases is reviewed in this article.

Key words: way caspase recruitment domain-containing protein, infectious diseases, innate immune, signal path