中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (4): 215-218.

• 论著 • 上一篇    下一篇

外用噻吗洛尔和激光治疗婴幼儿血管瘤疗效比较

林 晓，钱秋芳，黄 迎，陈茜岚   

  1. 上海市儿童医院，上海交通大学附属儿童医院皮肤科,上海 200062
  • 出版日期:2018-04-15 发布日期:2018-12-07
  • 通讯作者: 钱秋芳 E-mail:qianqf@shchildren.com.cn

Comparison of therapeutic efficacy between topical timolol maleate and PDL and ND: YAG laser in the treatment of superficial infantile hemangiomas

LIN Xiao，QIAN Qiufang，HUANG Ying，CHEN Xilan   

  1. Department of Dermatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China
  • Online:2018-04-15 Published:2018-12-07
  • Contact: QIAN QiufaQIAN Qiufang, E-mail: qianqf@shchildren.com.cn

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摘要： 目的：比较外用噻吗洛尔和激光治疗婴幼儿浅表型血管瘤的疗效。方法： 回顾性分析91例外用0.5%噻吗洛尔与85例PDL和Nd:YAG双波长激光治疗的婴幼儿浅表型血管瘤的疗效，瘤体连续2个月无继续改善停止治疗。结果： 噻吗洛尔组总有效率84.6%，激光组总有效率88.2%，差异无统计学意义（P＞0.05）。激光组平均治疗时间及瘤体消退76%～100%的时间分别为2.95±1.30和2.27±1.21个月，短于噻吗洛尔组的7.57±3.28和6.57±2.22个月，两组比较差异均有统计学意义（均P＜0.01）。结论： 两种方法治疗婴幼儿浅表型血管瘤疗效相近，激光治疗较外用噻吗洛尔控制快、疗程短。

关键词: 噻吗洛尔, 双波长脉冲激光, 婴幼儿血管瘤, 疗效

Abstract: Objective: To compare the efficacy of topical beta-blocker solution and PDL and ND: YAG laser in the treatment of the patients with superficial infantile hemangiomas. Methods: The data of 91 children with superficial infantile hemangiomas treated with topical 0.5% timolol maleate and 85 treated with dual-wavelength PDL and ND: YAG pulse laser of was retrospectively analyzed. Results: The total effective rates in the timolol maleate group and the laser group were 84.6% and 88.2%, with no significant difference (P＞0.05). The average treatment time and the time of lesions improvement 76%-100% in the laser group were 2.95±1.30 months and 2.27±1.21 months, which were shorter than that in the timolol maleate group (7.57±3.28 months and 6.57±2.22 months), with significant differences (Ps＜0.01). Conclusion: The laser is as?effective?as topical beta-blocker solution for treating infantile superficial hemangioma, but the effect is more quickly and the treatment time is shorter when treated with laser.

Key words: timolol, dual-wavelength pulse laser, infantile hemangiomas, treatment effect