中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (4): 222-225.

• 短篇论著 • 上一篇    下一篇

血清IL-26、HMGB1与带状疱疹相关性疼痛研究

李 蜜1,2 张怡萱1,2 刘莉萍1,2 李遇梅1，2   

  1. 1.江苏大学附属医院皮肤科，江苏，镇江，212001 2.江苏大学再生医学中心，江苏，镇江，212001
  • 出版日期:2018-04-15 发布日期:2018-12-07
  • 通讯作者: 李遇梅，E-mail:l.yumei@aliyun.com
  • 基金资助:
    [基金项目] 镇江市科技计划资助项目（SS2015024）; 2015年国家自然科学基金面上项目（编号：81573053）；2015江苏省“333工程”培养资金资助项目（编号：BRA2015196）

Correlation between serum IL-26,HMGB1 levels and herpes zoster-associated pain.

LI Mi1,2,ZHANG Yixuan1,2,LIU Liping1,2,LI Yumei1,2   

  1. 1. Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu, Zhenjiang, 212001, China； 2. Regenerative Medicine Center, Jiangsu University, Jiangsu ,Zhenjiang, 212001, China
  • Online:2018-04-15 Published:2018-12-07
  • Contact: LI Yu-mei, E-mail:l.yumei@aliyun.com

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摘要： 目的：探讨血清IL-26和高迁移率族蛋白1(HMGB1) 与急性带状疱疹疼痛(AHP)和后遗神经痛(PHN)之间的关系。方法： ELISA方法检测带状疱疹患者57例（AHP 40例， PHN17例）和健康对照组30例血清中IL-26、HMGB1的水平。结果：AHP组和PHN组IL-26平均水平分别为15.97±2.48 pg/mL，13.90±3.86 pg/mL高于对照组的8.00±0.38 pg/mL，差异有统计学意义；PHN组HMGB1平均水平为7.91±9.29 ng/mL明显高于AHP组3.80±6.30 ng/mL和健康对照组4.03±5.45 ng/mL（P<0.05）。AHP 组中疼痛VAS评分与血清IL-26浓度有相关性 (r=-0.435，P<0.05)，与HMGB1无相关性（r=0.109，P>0.05）。PHN组中疼痛VAS评分与IL-26和HMGB1水平均无相关性（P>0.05）。结论：IL-26可能与AHP的发病机制有关。

关键词: 带状疱疹, 白介素-26, 高迁移率族蛋白1, 神经疼痛

Abstract: Objective: To determine the correlation between serumIL-26, high mobility group box-1 protein (HMGB1) and acute herpes zoster pain (AHP) or posterior neuralgia (PHN). Methods: The expression levels of IL-26 and HMGB1 were detected by ELISA in 57 patients with herpes zoster (40 cases of AHP, 17 cases of PHN) and 30 healthy controls. Results: The average levels of IL-26 in the AHP group and PHN group were 15.97±2.48 pg/mL and 13.90±3.86 pg/mL, which were higher than that in control group (8.00±0.38 pg/mL), with a significant difference (P<0.05). The average level of HMGB1 in PHN group was 7.91±9.29 ng/mL, which was higher than those in AHP group (3.80±6.30 ng/mL) and control group (4.03±5.45 ng/mL), with significant differences (P<0.05). In AHP group, there was a correlation between VAS score and the level of serum IL-26 (r=-0.435，P<0.05). In the PHN group, there was no correlation between VAS score and the level of serum IL-26 or HMGB1. Conclusion: IL-26 may be involved in the pathogenesis of AHP.

Key words: Herpes zoster, interleukin-26, high mobility group protein 1, nerve pain