中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (5): 282-284.

• 短篇论著 • 上一篇    下一篇

超脉冲CO2激光联合布替萘芬软膏治疗甲真菌病的自身对照研究

祝伦1，蒋法兴2，汪蕾1，许蓉1，陈翔1   

  1. 1.铜陵市立医院皮肤科，安徽 铜陵244000；2.安徽医科大学附属省立医院皮肤科，安徽 合肥 230001
  • 出版日期:2018-05-15 发布日期:2018-12-10
  • 通讯作者: 蒋法兴，E-mail：jiangfxing@126.com

Self-control study of Ultra-pulse carbon dioxide laser combined with butenafine ointment in the treatment of onychomycosis

ZHU Lun1，JIANG Faxing2，WANG Lei1，XU Rong1，CHENG Xiang1   

  1. 1. Department of Dermatology，Tongling Municipal Hospital Dermatology，tongling244000，China；2. Department of Dermatology，Affiliated Provincial Hospital of Anhui Medical University，hefei230001, China
  • Online:2018-05-15 Published:2018-12-10

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摘要： 目的：评价超脉冲CO2激光联合布替萘芬软膏治疗甲真菌病的疗效和安全性。方法：从同一甲真菌病患者中随机挑选一个或多个病甲分别作为治疗组和对照组，治疗组采用超脉冲CO2激光联合布替萘芬软膏外用治疗，激光每周治疗一次，4次后，每4周一次，布替萘芬软膏每日2次，指甲治疗12～16周，趾甲治疗20～24周。对照组仅外用布替萘芬软膏。结果：共治疗19例甲真菌病患者131个病甲，其中治疗组为66个病甲，对照组为65个病甲。治疗组有效率为51.52%高于对照组的18.46%，两者差异有显著性(P＜0.05)；治疗组真菌镜检阴性率为66.67%高于对照组的26.15%，差异有显著性(P＜0.05)。结论：超脉冲CO2激光联合布替萘芬软膏治疗甲真菌病优于单用布替萘芬软膏。

关键词: 超脉冲CO2激光, 甲真菌病, 布替萘芬

Abstract: Objective： To evaluate the clinical efficacy and safety of the Ultra-pulse CO2 laser combined with topical butenafine therapy in the treatment of the patients with onychomycosis. Methods: The diseased nails were randomly selected and divided into the treatment group and control group in the same patient. The diseased nails in the treatment group were treated with ultra pulse CO2 laser (once a week initially and once four weeks after 4 times) combined with butenafine ointment twice a day, for 12～16 weeks on fingernails?and 20～24 weeks on toenails. The nails in the control group were treated with butenafine cream only. Results: Nineteen patients including 131 nails (66 in the treatment group and 65 in the control group) were enrolled into the study. The effective rates were 51.52% and 18.46% in the treatment group and in the control group, with a significant difference (P<0.01). The negativity rates of fungal microscopy was 66.67% and 26.15% in the treatment group and in the control group respectively, with a significant difference (P<0.01). Conclusion: Domestic super pulsed CO2 laser combined with butinafine ointment in the treatment of the onychomycosis nails is more effective than butinaphone ointment alone.

Key words: Ultra-pulse CO2 laser, onychomycosis, butenafine