中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (1): 18-21.doi: 10.12144/zgmfskin202301018

• 论著 • 上一篇    下一篇

199例带状疱疹后遗神经痛相关危险因素分析

思远,李璟蓉,李群,白靖竹,佘浠宁,莫友,吴江,方锐华   

  1. 广州市第一人民医院皮肤科，广东广州，510180
  • 出版日期:2023-01-15 发布日期:2022-11-25

Analysis of risk factors related to postherpetic neuralgia in 199 cases of herpes zoster

SI Yuan, LI Jingrong, LI Qun, BAI Jingzhu, SHE Xining, MO You, WU Jiang, FANG Ruihua   

  1. Department of Dermatology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China
  • Online:2023-01-15 Published:2022-11-25

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摘要： 目的：分析带状疱疹后遗神经痛(postherpetic neuralgia，PHN)发病相关因素，为临床PHN的预防和治疗提供依据。方法：采用回顾性分析，收集2015年8月至2020年6月广州市第一人民医院199例带状疱疹住院患者临床资料，根据皮疹消失后1个月是否有神经痛，分为PHN组57例和非PHN组142例。收集两组患者的年龄、性别、发病部位、发病时间、临床分型、急性期疼痛程度、血红蛋白水平、白蛋白水平、糖皮质激素使用情况以及是否合并高血压、糖尿病等临床资料。采用单因素及多因素Logistic回归分析。结果：单因素分析示：年龄、发病时间、临床分型、急性期疼痛程度以及白蛋白水平、血红蛋白水平具有统计学差异（P<0.05），而性别、发病部位、糖皮质激素治疗、是否患有高血压、糖尿病则无统计学差异（P>0.05）；多因素Logistic回归分析示：血红蛋白水平<120 g/L，年龄≥70岁、发病时间≥7天、临床分型为大疱型、急性期重度疼痛均为PHN发病的独立危险因素，而低白蛋白水平及未使用糖皮质激素不是PHN发病的独立危险因素（P>0.05）。结论：患者年龄≥70岁、发病时间≥7天、急性重度疼痛程度、临床分型为大疱型、血红蛋白水平＜120 g/L是PHN发生的危险因素。

关键词: 带状疱疹, 带状疱疹后遗神经痛, 危险因素, 低血红蛋白

Abstract:

Objective: To analyze the related factors of the pathogenesis of postherpetic neuralgia, and to provide the basis for the prevention and treatment of PHN. Methods: The clinical data of 199 patients with herpes zoster in Guangzhou First People's Hospital from August 2015 to June 2020 were retrospectively analyzed. According to whether there was neuralgia within 1 month after the rash disappeared, they were divided into PHN group of 57cases, and 142 cases in the non-PHN group. The factors such as age, gender, location, course, clinical classification, acute pain, hemoglobin level, albumin level, glucocorticoid use and whether combined with hypertension and diabetes were analyzed. Statistical analysis was performed using univariate and multivariate logistic regression. Results: Univariate analysis showed that age, course, clinical classification, acute pain, albumin and hemoglobin levels were statistically significant (P<0.05). Hypertension and diabetes were not statistically significant (P>0.05). Multivariate logistic regression analysis showed that the hemoglobin level <120 g/L, age ≥70 years, course≥7 days, clinical types of bullous type, severe pain in acute stage were independent risk factor of PHN. However, low albumin level and lack of glucocorticoid use were not independent risk factors for PHN (P>0.05). Conclusion: The age of patients ≥70 years old, course≥7 days, the degree of acute severe pain, the clinical classification of bullous type, and the hemoglobin level <120g/L are the risk factors for the occurrence of PHN.

Key words: herpes zoster, postherpetic neuralgia, risk factors, low hemoglobin