结外NK/T细胞淋巴瘤,皮肤结节,嗜酸性粒细胞增多," /> 结外NK/T细胞淋巴瘤,皮肤结节,嗜酸性粒细胞增多,"/> extranodal NK/T cell lymphoma, skin invasion, eosinophilia,"/> <span style="font-size:12px;">伴嗜酸性粒细胞增多的结外NK/T细胞淋巴瘤一例</span>

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (2): 127-130.doi: 10.12144/zgmfskin202402127

• 病例报告 • 上一篇    下一篇

伴嗜酸性粒细胞增多的结外NK/T细胞淋巴瘤一例

张蓓蓓1,刘立根2,宋宁静1   

  1. 1上海市同仁医院皮肤科，上海，200336；
    2上海市同仁医院血液科，上海，200336
  • 出版日期:2024-02-15 发布日期:2024-01-31

Rare extranodal NK/T cell lymphoma presenting as eosinophilic syndrome: a case report

ZHANG Beibei1, LIU Ligen2, SONG Ningjing1   

  1. 1 Department of Dermatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China;
    2 Department of Hematology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
  • Online:2024-02-15 Published:2024-01-31

PDF (PC)

108

摘要： 患者，男，53岁。反复双下肢结节红斑1年余，发热1个月余。入院前查血常规嗜酸性粒细胞 4.92×109/L(55.3%)，首诊为“嗜酸性粒细胞增多症”。入院后查EB病毒DNA阳性，下肢皮损病理检查：以血管为中心较致密的单一核细胞浸润，有异型性改变，及数量较多的嗜酸性粒细胞浸润。免疫组化：CD3（+），Ki67（80%），TIA1（+），Granzyme B（+），Perforin（+），EBER（+）。鼻黏膜及喉肿物活检见异型细胞。诊断：结外NK/T细胞淋巴瘤。

关键词: 结外NK/T细胞淋巴瘤')">">结外NK/T细胞淋巴瘤, 皮肤结节, 嗜酸性粒细胞增多

Abstract: A 53-year-old male presented with recurrent skin erythema and subcutaneous nodules of lower extremities for 1 year, fever for more than 1 month. Hematology findings showed a peripheral blood eosinophilic granulocyte count of 4.92×109/L (55.3%), Epstein-Barr virus DNA showed positive. Skin biopsy showed a dense infiltration of mononuclear cells surrounded blood vessels, with atypic changes and a large number of eosinophil infiltration. Immunohistochemistry: CD3(+), Ki67(80%), TIA1(+), Granzyme B(+), Perforin(+), EBER(+). Biopsy of nasal mucosa and laryngeal masses showed heterotypic cells. The diagnosis of extranodal NK/T cell lymphoma (ENKTL) was made.

Key words: extranodal NK/T cell lymphoma')">">extranodal NK/T cell lymphoma, skin invasion, eosinophilia