中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (8): 586-591.doi: 10.12144/zgmfskin202408586

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多发性骨髓瘤相关皮肤表现

赵安琪1,2,于越乾1,2,刘佳怡1,2,刘红1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2024-08-15 发布日期:2024-07-29

Cutaneous manifestations of multiple myeloma

ZHAO Anqi1,2, YU Yueqian1,2, LIU Jiayi1,2, LIU Hong1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China；2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2024-08-15 Published:2024-07-29

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摘要： 多发性骨髓瘤(multiple myeloma, MM)极少数情况下可累及皮肤。当前国内对于MM相关皮肤表现的报道多局限于皮肤转移，实际上MM相关皮肤表现多种多样。除皮肤继发浆细胞瘤外，还包括单克隆免疫球蛋白引起的皮肤表现以及一些病因不明的罕见表现。本文回顾了MM引起的常见及罕见皮肤表现，以便临床医生能够通过皮损尽早识别潜在的多发性骨髓瘤。

关键词: 多发性骨髓瘤, 免疫球蛋白轻链淀粉样变性, 冷球蛋白血症, 黄色瘤

Abstract: Multiple myeloma (MM) involved the skin rarely. At present, most domestic research on multiple myeloma-related skin manifestations is limited to skin metastasis. In fact, multiple myeloma-related skin manifestations are diverse. In addition to the most frequently reported secondary plasmacytoma of the skin, it also includes cutaneous manifestations due to monoclonal immunoglobulins and some rare manifestations of unknown etiology, etc. This paper reviews common and rare skin manifestations caused by multiple myeloma so that clinicians can identify potential multiple myeloma early by skin lesions.

Key words: multiple myeloma, systemic light chain amyloidosis, cryoglobulinemia, xanthomas