中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (12): 893-895.doi: 10.12144/zgmfskin202512893

• 病例报告 • 上一篇    下一篇

托法替布成功治疗光线性痒疹一例

魏婷1,2,3,张帆1,2,刘建新1,2,田洪青1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022;3泰安市中心医院，山东泰安，271000
  • 出版日期:2025-12-15 发布日期:2025-11-28

Actinic prurigo successfully treated with tofacitinib: a case report

WEI Ting1,2,3, ZHANG Fan1,2, LIU Jianxin1,2, TIAN Hongqing1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China; 3 Tai'an City Central Hospital, Tai'an 271000, China
  • Online:2025-12-15 Published:2025-11-28

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摘要： 患者，女，36岁，面、颈、耳后红斑、丘疹伴瘙痒反复发作4年。紫外线敏感性试验UVA-MED 4.1 J/cm2，UVB-MED 48.6 mJ/cm2。血IgE 1082 kU/L。诊断为光线性痒疹。给予口服托法替布5 mg每日2次，2天后瘙痒开始减轻，1周后皮损开始改善，2周后，面部、颈部、耳后皮损全部消退。无不良反应。随访1年无复发。

关键词: 托法替布, 光线性痒疹

Abstract: A 36-year-old female patient presented with recurrent erythema and papules on the face, neck, and retroauricular area accompanied with pruritis for 4 years. The ultraviolet light sensitivity test showed a UVA-MED value of 4.1 J/cm2, UVB-MED value of 48.6 mJ/cm2. Her serum IgE level was 1082 kU/L. The diagnosis of actinic prurigo was made. She was treated with oral tofacitinib 5 mg twice daily. Pruritus began to alleviate within 2 days, skin lesions started to improve after 1 week, and complete resolution of all lesions occurred within 2 weeks. No adverse reactions were reported, and no recurrence was observed during the 1-year follow-up period.

Key words: tofacitinib, actinic prurigo