中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (4): 248-252.doi: 10.12144/zgmfskin202504248

• 新发与再发感染性皮肤病 • 上一篇    下一篇

晚期艾滋病合并猴痘七例临床特征及预后分析

杨慧勤,曾谋,郑海鹏,陈旭丹,陈劲峰,张坚生,李凌华,王建   

  1. 广州医科大学附属市八医院感染病中心，广东广州，510440
  • 出版日期:2025-04-15 发布日期:2025-04-08

Clinical features and prognosis of 7 cases with advanced AIDS co-infected with mpox

YANG Huiqin, ZENG Mou, ZHENG Haipeng, CHEN Xudan, CHEN Jinfeng, ZHANG Jiansheng, LI Linghua, WANG Jian   

  1. Infectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China
  • Online:2025-04-15 Published:2025-04-08

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摘要： 目的：分析晚期艾滋病合并猴痘患者的临床特征及预后。方法：回顾性分析2023年6月至2024年7月我院收治的7例晚期AIDS合并猴痘患者的临床资料。结果：7例患者均为男同性恋，中位年龄30岁，CD4+ T淋巴细胞计数中位数为90个/μL。7例患者皮疹以焦痂、溃疡为主。5例出现并发症，其中3例出现皮肤软组织感染和以肛瘘为主的肛周并发症。3例合并机会性感染，以巨细胞病毒（CMV）血症为主。7例患者均接受高效抗逆转录病毒治疗（HARRT）治疗，2例患者出院后未坚持HARRT治疗，其中1例死亡，1例马尔尼菲篮状菌再感染，5例坚持HARRT的患者痊愈且CD4+ T淋巴细胞计数显著提升。结论：晚期AIDS合并猴痘患者皮疹严重，并发症多，坚持HARRT治疗可获得免疫重建，提高治疗效果。

关键词: AIDS, 猴痘, HARRT, 免疫重建

Abstract: Objective: To analyze the clinical features and prognosis of advanced AIDS patients with mpox. Methods: The clinical data of 7 patients with advanced AIDS complicated with mpox admitted to our hospital from June 2023 to July 2024 were retrospectively analyzed. Results: All 7 patients were gay men with a median age of 30 years and a median CD4+ T lymphocyte count of 90/μL. The rashes of 7 patients were mainly eschar and ulcer. Complications occurred in 5 cases, of which 3 cases had skin and soft tissue infection and perianal complications mainly anal fistula. Three cases had opportunistic infection, mainly cytomegalovirus (CMV). All 7 patients received highly active antiretroviral therapy (HARRT), 2 patients did not adhere to HARRT treatment after discharge, of which one died, another was re-infected with Marneffei bacillus, and 5 patients who insisted on HARRT were cured and had an increase in the number of CD4+ T lymphocytes. Conclusion: Patients with advanced AIDS complicated with mpox have severe rashes and more complications, and can obtain immune reestablishment by adhering to HARRT treatment.

Key words: AIDS, mpox, HARRT, immune reconstitution