中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (6): 433-435.doi: 10.12144/zgmfskin202506433

• 临床研究 • 上一篇    下一篇

5-盐酸氨基酮戊酸光动力诱发儿童光线性甲分离三例并文献复习

孙晓静,柳赛赛,吴王丽,杨永华,于学红   

  1. 山东大学附属威海市立医院，山东威海，264200
  • 出版日期:2025-06-15 发布日期:2025-05-23

Photo-onycholysis induced by photodynamic therapy with 5-aminolevulinic acid in children: three cases report and literature review

SUN Xiaojing, LIU Saisai, WU Wangli, YANG Yonghua, YU Xuehong   

  1. Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai 264200, China
  • Online:2025-06-15 Published:2025-05-23

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摘要： 光线性甲分离通常由紫外线辐射增强引发，较少见。本文报道3例难治性甲周疣患儿在接受5-盐酸氨基酮戊酸光动力（ALA-PDT）治疗两次后出现远端半月形甲分离，诊断为光线性甲分离。患儿口服多维元素片治疗2~3个月甲床恢复正常。本文不仅揭示了光动力疗法在治疗儿童甲周疣时可能存在的不良反应，同时也为光线性甲分离的临床诊治提供了参考。

关键词: 5-氨基酮戊酸, 光动力学疗法, 光线性甲分离, 甲周疣

Abstract: Photo-onycholysis is a rare form of nail separation, usually triggered by enhanced ultraviolet radiation. This article reports three cases of children with refractory periungual warts who developed distal lunula-like nail separation after two times of 5-aminolevulinic acid photodynamic therapy (ALA-PDT). Three children were diagnosed as photo-onycholysis, and were treated with oral multivitamin tablets for 2-3 months, then the nail beds returned to normal. This article not only reveals the potential adverse reactions of ALA-PDT in the treatment of periungual warts in children but also provides a reference for the treatment of photo-onycholysis.

Key words: 5-aminolevulinic acid, photodynamic therapy, photo-onycholysis, periungual warts