中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (1): 35-38.doi: 10.12144/zgmfskin202601035

• 临床研究 • 上一篇    下一篇

手术联合光动力治疗外阴恶性肿瘤三例

孟小南1,郭海霞2   

  1. 1天津中医药大学,天津，301617；2天津市中医药研究院附属医院皮肤外科，天津，300120
  • 出版日期:2026-01-15 发布日期:2026-01-15

Three cases of vulvar malignant tumors treated by surgery combined with photodynamic therapy

MENG Xiaonan1, GUO Haixia2   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; 2 Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
  • Online:2026-01-15 Published:2026-01-15

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摘要： 外阴皮肤恶性肿瘤首选手术切除，但存在因解剖复杂致缺损难以缝合、缩小切缘会增肿瘤残留风险以及部分高龄患者不耐受手术等问题。光动力疗法可作为有效的术后辅助手段清除潜在病灶。本文报道手术联合光动力治疗外阴恶性肿瘤3例。3例患者均经病理确诊且未发生转移，患者接受手术切除后联合外用氨基酮戊酸光动力治疗3次。3例患者随访时间分别为2年、1年、6个月，均无复发，所有患者未遗留显著功能障碍或美容缺陷。本文证实手术联合外用ALA-PDT是治疗外阴皮肤恶性肿瘤的一种有效方案。

关键词: 光动力, 氨基酮戊酸, 外科手术, 外阴恶性肿瘤, 鲍温病, 乳房外Paget病

Abstract: Surgical resection is the first-line treatment for vulvar cutaneous malignant tumors, but it is associated with several challenges: difficult-to-suture soft tissue defects due to complex vulvar anatomy, increased risk of tumor residue when reducing surgical margins to close the wound, and poor tolerance to prolonged surgery in some elderly patients. Photodynamic therapy (PDT) can serve as an effective postoperative adjuvant modality to eliminate potential residual lesions. This article reports 3 cases of vulvar malignant tumors treated with surgery combined with PDT.All 3 patients were pathologically confirmed without metastasis and had no significant medical history. After surgical resection, they received topical 5-aminolevulinic acid (ALA)-based PDT for 3 sessions. Three patients were followed up for 2 years, 1year, and 6 months, respectively with no reccurrence. None of the patients had residual significant functional impairment or cosmetic defects.This study confirms that surgery combined with topical ALA-PDT is an effective therapeutic regimen for vulvar cutaneous malignant tumors.

Key words: photodynamic, aminoketoglutaric acid, surgery, vulvar malignancy, Bowen's disease, extramammary Paget's disease