中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (3): 199-202.doi: 10.12144/zgmfskin202603199

• 临床研究 • 上一篇    下一篇

阿普米司特治疗玫瑰痤疮伴皮肤垢着病一例并文献复习

吴恺悦1,2,3,房胜珂2,3,李建可2,3,于咏梅2,3,刘国艳2,3   

  1. 1山东中医药大学，山东济南,250014；2山东第一医科大学附属皮肤病医院，山东济南,250022；3山东省皮肤病性病防治研究所，山东济南,250022
  • 出版日期:2026-03-15 发布日期:2026-03-10

Apremilast for the treatment of rosacea with cutaneous dirt-adherent disease: a case report and literature review

WU Kaiyue1,2,3, FANG Shengke2,3, LI Jianke2,3, YU Yongmei2,3, LIU Guoyan2,3   

  1. 1 Shandong University of Traditional Chinese Medicine, Jinan 250014, China; 2 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 3 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2026-03-15 Published:2026-03-10

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摘要： 皮肤垢着病(cutaneous dirt-adhering disease, CDAD) 病因尚不明确，可独立发生，也可继发于红斑型天疱疮、银屑病、痤疮等疾病，多数患者伴有精神心理障碍。本文患者皮肤垢着病继发于玫瑰痤疮，该患者反复发作，面部反复红斑、丘疹半年，伴褐色结痂1个月，口服盐酸多西环素、雷公藤多苷片后无明显改善，遂予阿普米司特治疗，玫瑰痤疮及皮肤垢着病皮损逐渐消退。我们分析本患者因心理精神因素，激活下丘脑-垂体-肾上腺轴促进IL-1β、肿瘤坏死因子等炎症因子的释放加剧炎症反应，促进皮脂的分泌，引发CDAD，阿普米司特可通过靶向抑制PDE-4，减少炎性细胞因子的表达，从而抑制炎症反应，改善玫瑰痤疮的症状，油脂的分泌减少进一步改善CDAD的症状。

关键词: 阿普米司特, 皮肤垢着病, 玫瑰痤疮

Abstract: The etiology of cutaneous dirt-adhering disease (CDAD) remains unclear, it can occur independently or secondary to diseases such as erythematous pemphigus, psoriasis, and acne, and most patients are complicated with mental and psychological disorders. This patient suffered from recurrent rosacea. In this case, the patient's cutaneous dirt-adherent disease was secondary to roseacea. The patient had vecurrent facial erythema and papules for half a year, accompanied by brown crusting for one month. which showed no significant improvement after oral administration of doxycycline hyclate and tripterygium glycosides tablets, so apremilast was given for treatment, and the skin lesions of rosacea and CDAD gradually subsided. We analyzed that in this patient, mental and psychological factors activated the hypothalamic-pituitary-adrenal axis, which promoted the release of inflammatory factors such as IL-1β and tumor necrosis factor, exacerbated the inflammatory response, and stimulated sebum secretion, thereby inducing CDAD. Apremilast can target and inhibit PDE-4, reduce the expression of inflammatory cytokines, so as to inhibit the inflammatory response and improve the symptoms of rosacea, the reduced sebum secretion further ameliorates the symptoms of CDAD.

Key words: apremilast, cutaneous dirt-adherent disease, rosacea