中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (6): 417-420.doi: 10.12144/zgmfskin202606417

• 论著 • 上一篇    下一篇

四例皮肤颗粒细胞瘤临床病理分析

文豪,王舒靖,孟祥羽,邹宇洁,沈一菲,彭琳琳   

  1. 大连市皮肤病医院病理科，辽宁大连，116000
  • 出版日期:2026-06-15 发布日期:2026-06-04

Clinical and pathological analysis of 4 cases with cutaneous granular cell tumor

WEN Hao, WANG Shujing, MENG Xiangyu, ZOU Yujie, SHEN Yifei, PENG Linlin   

  1. Department of Pathology, Dalian Dermatology Hospital, Dalian 116000, China
  • Online:2026-06-15 Published:2026-06-04

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摘要： 颗粒细胞瘤（granular cell tumor,GCT）是罕见的良性软组织肿瘤，临床表现缺乏特异性，易误诊。本文回顾性分析2020年1月至2025年1月大连市皮肤病医院确诊的4例皮肤GCT患者的临床特征、组织病理学表现及免疫表型，以提高皮肤科医生对该病的认识与诊疗水平。4例患者均为女性，年龄35～50岁，平均42.25岁；病程1～4年，平均2年；发病部位涉及外阴、头皮、后颈部及腹部，肿物平均直径约2.5 cm，其中2例伴有疼痛症状。组织病理示肿瘤细胞弥漫分布呈片状、巢状或条索状，细胞呈多边形或卵圆形，核小、胞浆丰富且富含嗜酸性颗粒。免疫组化示4例均为S-100阳性、SOX10阳性、CD68阳性、Vimentin阳性，Desmin、MelanA、CK（AE1/AE3）均为阴性，Ki-67阳性指数＜5%。所有患者均行手术完整切除肿物，随访12～37个月，均无复发。

关键词: 颗粒细胞瘤, 皮肤肿瘤, 病理诊断

Abstract: Granular cell tumor (GCT) is a rare benign soft tissue tumor with nonspecific clinical manifestations, leading to frequent misdiagnosis. We retrospectively analyzed the clinical, histopathological and immunohistochemical features of 4 cases of cutaneous GCT diagnosed at Dalian Dermatosis Hospital from January 2020 to January 2025, to improve its recognition and management. All 4 patients were female, aged 35-50 years with a mean age of 42.25 years; the disease course ranged from 1 to 4 years with an average of 2 years. The lesions were located on the vulva, scalp, posterior neck and abdomen, with a mean tumor diameter of approximately 2.5 cm, and 2 cases were accompanied by pain. Histopathology showed that tumor cells were diffusely distributed in sheets, nests or cords, with polygonal or oval cells, small nuclei, and abundant cytoplasm rich in eosinophilic granules. Immunohistochemical staining revealed that all 4 cases were positive for S-100, SOX10, CD68 and Vimentin, and negative for Desmin, MelanA and CK (AE1/AE3), with a Ki-67 proliferation index of ＜5%. All patients underwent complete surgical resection, and no recurrence was observed during the follow-up period of 12-37 months.

Key words: granular cell tumor, cutaneous tumor, pathological diagnosis