中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (6): 437-440.doi: 10.12144/zgmfskin202606437

• 临床研究 • 上一篇    下一篇

钝性剥离联合ALA-PDT治疗甲下疣及甲周疣八例临床分析

史金龙,付黎影,张阳,李天举   

  1. 河南中医药大学第五临床医学院（郑州人民医院），河南郑州，450053
  • 出版日期:2026-06-15 发布日期:2026-06-04

Clinical analysis of 8 cases with subungual and periungual warts treated with blunt dissection combined with ALA-PDT

SHI Jinlong, FU Liying, ZHANG Yang, LI Tianju   

  1. The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou 450053, China
  • Online:2026-06-15 Published:2026-06-04

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摘要： 目的：初步探讨钝性剥离术联合5-ALA-PDT治疗难治性甲下疣及甲周疣的临床疗效与安全性。方法：回顾性分析2021年3月至2023年5月收治的8例对常规治疗抵抗的甲下疣及甲周疣患者，均接受1次钝性剥离术及1~2次5-ALA-PDT治疗。采用视觉模拟评分法（VAS）评估治疗相关疼痛，术后对患者进行6~12个月随访，观察皮损清除、甲板再生、复发及不良反应发生情况。结果：8例患者疣体均完全清除，临床治愈率为100%；随访期间无一例复发，所有患者甲板再生良好，未出现甲床瘢痕或永久性甲畸形。治疗过程中疼痛VAS评分为3~5分，经对症处理后均可耐受。结论：钝性剥离联合ALA-PDT治疗难治性甲下疣及甲周疣可彻底清除疣体、保护甲单元结构、有效降低复发率。

关键词: 甲下疣, 甲周疣, 钝性剥离, 5-ALA-PDT

Abstract: Objective: To preliminarily investigate the clinical efficacy and safety of blunt dissection combined with 5-ALA-PDT in the treatment of refractory subungual and periungual warts. Methods: A retrospective analysis was conducted on 8 patients with subungual and periungual warts resistant to conventional therapies admitted between March 2021 and May 2023. All patients underwent one session of blunt dissection followed by 1-2 sessions of ALA-PDT. Treatment-related pain was assessed using the Visual Analog Scale (VAS). Patients were followed up for 6 to 12 months to observe lesion clearance, nail plate regeneration, recurrence and adverse reactions. Results: Complete clearance of warts was achieved in all 8 patients with a clinical cure rate of 100%. No recurrence was observed during the follow-up period. All patients had satisfactory nail plate regeneration without nail bed scarring or permanent nail deformity. The pain VAS scores during treatment ranged from 3 to 5, which were tolerable after symptomatic management. Conclusions: Blunt dissection combined with ALA-PDT in the treatment of refractory subungual warts and periungual warts can completely clear the warts, protect the nail unit structure, and effectively reduce the recurrence rate.

Key words: subungual warts, periungual warts, blunt dissection, 5-ALA-PDT