中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (7): 411-413.

• 论著 • 上一篇    下一篇

5-氨基酮戊酸光动力治疗宫颈环状电切术后高危HPV感染的疗效评价

孟宪敏 石秀艳 刘 薇 王红英 王 冲 马倩倩 栾红   

  1. 山东省聊城市人民医院皮肤科，252000
  • 出版日期:2018-07-15 发布日期:2018-12-14
  • 通讯作者: 栾红，E-mail：lcsrmyy@126.com

Efficacy of topical photodynamic therapy with 5-aminolevulinic acid on treating high risk human papilloma virus infection after loop electrosurgical excision procedure

MENG Xianmin, SHI Xiuyan, LIU Wei,WANG Hongying,WANG Chong, MA Qianqian,LUAN Hong   

  1. Department of Dermatology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, China
  • Online:2018-07-15 Published:2018-12-14
  • Contact: LUAN Hong，E-mail：lcsrmyy@126.com

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摘要： 目的：评价5-氨基酮戊酸光动力治疗宫颈环状电切术后高危型人乳头瘤病毒（HR-HPV）感染的疗效。方法： 收集我院2015年1月至2016年6月经宫颈环状电切术治疗的宫颈上皮内瘤变Ⅱ级、术后6个月液基薄层细胞（TCT）检测无异常、HR-HPV检测持续阳性患者。随机分成治疗组和对照组，治疗选在非月经期，治疗组给予光动力治疗，每周1次，连续治疗3次；对照组，给予干扰素治疗，每日用药1次，每次用量为80万IU，每个月经周期使用10次，连续3个月。结果：共42例患者入选，治疗组（20例）和对照组（22例）12个月HR-HPV转阴率分别为80%和36%，差异有统计学意义(P<0.05)。结论：5-氨基酮戊酸光动力治疗宫颈环状电切术后高危HPV感染有效。

关键词: 光动力, 宫颈上皮内瘤变, 宫颈环状电切术, 人乳头瘤病毒

Abstract: Objective: To assess the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating high risk human papilloma virus (HR-HPV) infection after loop electrosurgical excision procedure (LEEP). Methods：The patients with cervical intraepithelial neolasia Ⅱtreated by loop electrosurgical excision procedure, with normal Thinprep Cytologic Test (TCT) for 6 months and positivity for HR-HPV were selected from January 2015 to June 2016. The patients were divided into the treatment group and control group randomly. The patients in the treatment group were treated with 5-aminolevulinic acid photodynamic therapy (ALA-PDT), once a week, for 3 times. The patients in the control group were treated with interferon, 800 000 IU, once a day, 10 times each menstrual cycle for 3 months. Results: Forty-two patients were collected. The HR-HPV negative conversion?rates were?80% in?the treatment?group?(20 patients) and 36% in the control group, with a significant difference (P<0.05). Conclusion：ALA-PDT is effective in the treatment of HR-HPV after LEEP.

Key words: ALA-PDT, cervical intraepithelial neoplasias, loop electrosurgical excision procedure, high risk human papilloma virus