China Journal of Leprosy and Skin Diseases ›› 2019, Vol. 35 ›› Issue (2): 65-69.doi: 10.12144/zgmfskin201902065

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The establishment and application of leprosy biobank

WANG Zhenzhen1,2,3，LIU Hong1,2,3，WANG Chuan1,2,3，YU Gongqi1,2,3，FU Xi'an1,2,3，BAO Fangfang1,2,3，SUN Yonghu1,2,3，MI Zihao1,2,3，SUN Lele1,2,3，PAN Qing1,2,3，CHU Tongsheng1,2，ZHOU Guizhi1,2，XIONG Li4，YANG Jun4，YANG Rongde4，LI Jinlan5，KE Wei5，NING Yong6，XIONG Junhao6，LI Ming7，XIONG Mingzhou7，YANG Bin7，DUAN Qizhi8，WANG Hong8，LI Wei8，KUANG Yanfei9，LI Junhua9，WANG Lamei10，CAO Qiuyang10，XIAO Peng11，XIAO Bangzhong11，ZHANG Lianhua12，LIN Zhaoxing13，WANG Yaofei13，SHEN Yunliang14，YAN Liying14，WU Wenbin15，ZHENG Hu16，ZHAN Xianfa17，LI Wanghua17，SHANG Xiujian18，XU Yujun19，LIU Qiao19，YAN Liangbin20，ZHANG Guocheng20，CHEN Shumin1,2，ZHANG Furen1,2,3,21,22   

  1. 1. Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China; 
    2. Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan 250022, China; 
    3. Shandong Provincial Key Lab for Dermatovenereology, Jinan 250022, China; 
    4. Yunnan Provincial Center for Disease Control and Prevention, Kunming 650100, China; 
    5. Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China; 
    6. Sichuan Provincial Institute of Dermatology, Chengdu 610014, China; 
    7. Guangdong Provincial Institute of Dermatology, Guangzhou 510098, China; 
    8. Guangxi Provincial Institute of Dermatology, Nanning 530000, China; 
    9. Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China; 
    10. Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330046, China; 
    11. Chongqing Center for Disease Control and Prevention, Chongqing 400042, China; 
    12. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China; 
    13. Shanxi Provincial Institute for Endemic Disease Control, Xian 710003, China; 
    14. Zhejiang Provincial Institute of Dermatology, Huzhou 313200, China; 
    15. Fujian Center for Disease Control and Prevention, Fuzhou 350001, China; 
    16. Anhui Provincial Institute of Dermatology, Hefei 230000, China;  17. Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China;  18. Xinjiang Center for Disease Control and Prevention, Urumchi 830001, China;   19. Hainan Provincial Center for Skin Disease and STI Control, Haikou 571199, China;   20. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 21. School of Medicine, Shandong University, Jinan 250000, China;  22. University of Jinan, Shandong Academy of Medical Science, Jinan 250000, China
  • Online:2019-02-20 Published:2019-03-07
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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Abstract: Objective: To establish a biobank for leprosy and provide biological resources for solving the key scientific problems of "eliminating leprosy hazard". Methods: We collected blood and tissue samples with the help of leprosy prevention staff from each provinces. All kinds of samples were extracted by using the related technologies, and then imported the data into the biobank management system and stored the samples into the biobank. Results: The preparing work of biobank began in 2005. As of Feb 28, 2017, 81,532 samples (including both Han and 18 ethnic minorities) from 19 provinces have been collected, covering 35,268 tissue samples, 33,320 blood samples and 12,944 microbiological specimens (Nasal swab). Based on these resource, our team conducted a series research initiatives involving genetic background of leprosy and risk factor of dapsone hypersensitivity syndrome as well. Conclusion: The largest leprosy Biobank in the world has been successfully established which makes our team has achieved original findings in leprosy research and in order to complete China's long-term plan for the elimination of leprosy (2011-2020), also it has laid the foundation for the world health organization to contribute Chinese wisdom to "creating a world free of leprosy".

Key words: leprosy, biobank, application