Abstract: Objective: To detect the expression of M1/M2 macrophages in the lessions of condyloma acuminatum(CA). Methods: The expression  of iNOS-labeled M1 macrophages and CD163-labeled M2 macrophages were detected by immunohistochemistry streptavidin-peroxidase methodin in CA lesions of 30 patients and15 normal controls. Results: The number of iNOS+ M1 macrophage in CA lesions and normal tissues was (6.16±3.32)/HP and (6.76±0.87)/HP, with no significant difference (P>0.05). The number of CD163+M2 macrophages in CA lesions and normal tissue was (22.30±6.27)/HP and (9.81±4.23)/HP，with a significant difference (P<0.05). There was a negative correlation between the level of iNOS+ M1 and CD163+ M2 macrophages in CA lesions (P<0.05). Conclusion: Macrophages infiltration in CA lesions mainly are M2, which may play an important role in CA escaping immune responses.

Key words: condyloma acuminata, M1 macrophages, M2 macrophages, iNOS, CD163