Abstract: We report 3 cases of angioma serpiginosum (AS) diagnosed in our hospital and reviewed the related literature from CNKI and PUBMED database, in order to increase the knowledge of this disease. The result showed a total of 122 AS patients were analyzed, the ratio of male to female was 1:1.8. The average age of onset was 12.4 years old. The age of onset in 79.6% patients were younger than 18 years old. 69.7% patients had unilateral lesions which manifested as multiple pinhead-size red or purplish red spots, scattered or clustered, in the pattern of serpentine or ring development. Histopathology showed that the epidermis was generally normal, with dilatation and/or hyperplasia of capillaries in the superficial dermis, without hemosiderin deposition or erythrocyte extravasation and inflammatory cell infiltration. The dermoscope showed multiple well-defined red lagoons from round to oval. The treatment was mainly treated with vascular laser and showed good efficacy.

Key words: angioma serpiginosum, clinical characteristics, dermoscopy, histopathology