China Journal of Leprosy and Skin Diseases ›› 2021, Vol. 37 ›› Issue (11): 744-747.doi: 10.12144/zgmfskin202111744

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Update of intercellular adhesion molecule CD146 in skin diseases

WANG Zhe, LIU Hong, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University, Jinan 250022, China
  • Online:2021-11-15 Published:2021-09-15
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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Abstract: CD146 is an adhesion molecule, which is mainly expressed by vascular endothelial cells. Recent studies have shown that CD146 plays an important role in several skin diseases. Three forms of CD146 have been described, including two transmembrane isoforms and a soluble protein. CD146 can mediate pleiotropic biological functions through interactions with different ligands. The update of the structure, location, regulation and function of CD146 molecules and research progress in skin diseases is reviewed in this article.

Key words: CD146, skin diseases