Abstract: Lichen sclerosus is a chronic inflammatory skin disease that most often involves female genital skin, which seriously affects the quality of life of patients. The exact pathogenesis of the disease is still unclear and the treatment is controversial. Understanding the immunological and molecular biological mechanisms of the disease can help provide new options for the treatment of the disease and provide new ideas for future basic research of lichen sclerosus. In this paper, we review the progress of research on the immunological and molecular biological mechanisms of lichen sclerosus.

Key words: lichen sclerosus, immunity, cytokine, biomacromolecule