Abstract: One case presented with multiple nodules and ulcers with fever for 1 month. Biopsy showed infectious granuloma and Haemophilus was indentified by PCR, the patient was cured after treated with ciprofloxacin, clarithromycin and isoniazid for 1 year. This patient suffurred from systemic lupus erythematosus and lupus nephritis from 2016 and given the therapy of peritoneal dialysis, oral glucocorticoids and immunosuppressants. Another case presented with ulcers on lower extremity with pain for 3 months, biopsy showed infectious granuloma and Mycobacterium Avium was indentified by PCR, the patient refused treatment. However, the patient's condition worsened at the patient's return visit after 3 months. We treated the patient with ethambutol, clarithromycin, rifampicin and the patient is under follow-up. This patient had a history of kidney transplantation for chronic renal failure 7 years ago and regular use of tacrolimus capsule, metecocorticoid tablet, glucocorticoid. Skin nodules, abscesses, and ulcers in patients with prolonged use of  immunosuppressant and glucocorticoid should be considered NTM infection.

Key words: nontuberculous mycobacterium, cutaneous infection, immunosuppressive agents, Haemophilus, Mycobacterium avium