Abstract: Objective: To analyze the susceptibility of Mycobacterium abscess isolated from skin and soft tissue infection in vitro. Methods: Strains isolated from clinical samples of patients with Mycobacterium abscessus in our hospital from September 2019 to June 2021. The minimum inhibitory concentrations of clarithromycin, azithromycin, amikacin, moxifloxacin, ciprofloxacin, minocycline, meropenem, linezolid, isoniazid, rifampicin and cefoxitin on the Mycobacterium abscessus were detected by microbroth dilution method. The standard strain of Mycobacterium abscessus (ATCC19977) were used as control. Results: Eleven strains were collected. Mycobacterium abscessus are sensitive to clarithromycin (100%), amikacin (100%), linezolid (100%), cefoxitin (100%) and cefmetazole (100%) . The drug resistance rate of Mycobacterium abscessus to isoniazide, rifampicin and minocycline was 100%, that to meropenem and ciprofloxacin was 91.7%. Conclusion: According to the result of drug sensitivity tests in vitro, clarithromycin, amikacin, linezolid cefoxitin and cefmetazole can be used as the first choice for the treatment of Mycobacterium abscessus infection of skin. Isoniazid, rifampicin, minocycline, meropenem and ciprofloxacin are not recommended for the treatment of Mycobacterium abscessus infection of skin.

Key words: Mycobacterium abscessus, antibiotics, minimum inhibitory concentration, cutaneous infection