Abstract: A case of pyoderma gangrenosum successfully treated with adalimumab was reported and relevant literatures are reviewed. The case was a 53-year-old male with erythema and papules on the left inner thigh for 6 months and ulcers for 3 months. The pathological features were accordance with pyoderma gangrenosum.  He was treated with tripterygium wilfordii polyglycosides and thalidomide tablets on the first day after being diagnosed, but there were still new erythema and papules after 3 days. Adalimumab 80mg and 40mg were given on the third day and the 10th day respectively. Then, adalimumab was injected subcutaneously, 40mg, every 2 weeks, and the ulcer healed when the fourth dose of adalimumab was injected.The skin lesions did not recur after six months of follow-up.

Key words: TNF-alpha antagonist, adalimumab, pyoderma gangrenosum