Abstract: A 45-year-old male presented with scalp papules, nodules, abscesses, and recurrent ulceration accompanied by pain for 5 years. He was diagnosed with perifolliculitis capitis abscedens et suffodiens. After an unsatisfactory response to conventional treatment, the patient was treated with adalimumab. After four and a half months of treatment, significant alleviation of pain, shrinkage of nodules, resolution of inflammation, and reduction or cessation of purulent discharge were observed. The patient is currently undergoing continuous treatment and follow-up. Some literature has reported on the clinical efficacy of TNF-α inhibitors in treating PCAS. This paper conducts a retrospective analysis of the treatment of the present case and previous literature.

Key words: perifolliculitis capitis abscedens et suffodiens, dissecting cellulitis of the scalp, TNF-α inhibitors, adalimumab