Abstract: Multiple myeloma (MM) involved the skin rarely. At present, most domestic research on multiple myeloma-related skin manifestations is limited to skin metastasis. In fact, multiple myeloma-related skin manifestations are diverse. In addition to the most frequently reported secondary plasmacytoma of the skin, it also includes cutaneous manifestations due to monoclonal immunoglobulins and some rare manifestations of unknown etiology, etc. This paper reviews common and rare skin manifestations caused by multiple myeloma so that clinicians can identify potential multiple myeloma early by skin lesions.

Key words: multiple myeloma, systemic light chain amyloidosis, cryoglobulinemia, xanthomas