Abstract: A 69-year-old female patient was diagnosed with multiple myeloma (MM) three months ago. Exposure to cold weather triggered symptoms such as purpura, ecchymosis, joint swelling, and pain in her extremities. Her serum light chain kappa levels were notably elevated. Protein fixation electrophoresis positive for monoclonal immunoglobulin IgG, monoclonal kappa light chain (κ), and cryoglobulinemia test. Consequently, secondary type Ⅰ cryoglobulinemia was diagnosed. Given the association between the patient's MM and cryoglobulinemia, the hematology department adjusted the chemotherapy regimen, a topical mucopolysaccharide polysulfate cream was applied to the affected skin areas additionally, and efforts were made to keep her acra warm. After two months, the patient's ecchymosis completely resolved.

Key words: multiple myeloma, type I cryoglobulinemia, vasculitis