Abstract: In recent years, scientific research has revealed that hair follicle stem cells and their niche play a key role in maintaining tissue homeostasis and promoting hair growth cycle, which opens up new perspectives and strategies for hair loss treatment. With age, the activity and function of hair follicle stem cells gradually decreases, and the ability of hair follicles to self-repair and regenerate is weakened. This paper reviewed the basic contents of hair follicle stem cells and niche, and the internal and external mechanisms of the aging process of hair follicle stem cells, in order to bring new inspirations for the treatment of hair loss.

Key words: hair loss, HFSCs, niche, cell aging