成纤维细胞在皮肤病中的作用

doi:10.12144/zgmfskin202504308

Abstract

Abstract: As the largest organ of the body, the health status of the skin is influenced by a variety of cells, among which fibroblasts play an extremely important role. This paper summarizes the functions of fibroblasts in skin diseases, covering their roles in fibrosis, immune regulation, tumor development, pigmentation, hair follicle development, and skin aging. In addition, this paper also explores therapeutic strategies targeting fibroblasts to provide new perspectives for the clinical treatment of skin diseases.

Key words: fibroblasts, function, skin diseases, therapeutic strategies

GUAN Zepu, SHE Xinyan, LIN Junjie, LI Yang, CAI Liting, WANG Xiaohua. The role of fibroblasts in skin diseases[J].China Journal of Leprosy and Skin Diseases, 2025, 41(4): 308-313.

[1]	YAO Xinyi, HE Tong, YANG Xinya, XU Mingcheng, ZHANG Junling. Research progress on interleukin-17C in autoimmune skin diseases [J]. China Journal of Leprosy and Skin Diseases, 2025, 41(1): 69-72.
[2]	WANG Yi, ZHAO Qing, MI Zihao, LIU Hong, Zhang Furen. Comparison of the adverse effects of long-term use of conventional immunosuppressive agents in dermatology patients with dermatosis [J]. China Journal of Leprosy and Skin Diseases, 2024, 40(5): 311-316.
[3]	LI Jianghui, YAN Xiaoning, FU Jiaying, HU Haoyuan. Update of the epidemiology and pathogenic risk factors of prurigo nodularis [J]. China Journal of Leprosy and Skin Diseases, 2024, 40(11): 830-834.
[4]	CHEN Leigang, REN Huimin, WU Yuanhui, AN Guozhi, JING Xiaolei, ZHAO Tongxin. The effect and mechanism of Hypocrellin A promotes apoptosis of Keloid fibroblasts through ROS/JNK pathway [J]. China Journal of Leprosy and Skin Diseases, 2023, 39(12): 868-873.
[5]	LIN Xiuqiu, OU Min, YAN Yunling, XIAO Weiju, WANG Xiaohua. Update of cutaneous Mycobacterium infection [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(1): 60-64.
[6]	QIU Xie, LEI Tiechi, HAN Bingyu, YAO Yunzhu, LIAO Zhikai, HU Shuanghai. Improvement effect of fetal dermal fibroblasts intradermal injection on the photoaged mouse skin induced by UV [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(7): 413-418.
[7]	TANG Wen, CHEN Aijun. Update of tranexamic acid in dermatology [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(3): 180-184.
[8]	WANG Zhe, LIU Hong, ZHANG Furen. Update of intercellular adhesion molecule CD146 in skin diseases [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(11): 744-747.
[9]	CHEN Lihao, JIANG Juan. Update of pathogenesis of sensitive skin and related skin diseases [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(8): 505-508.
[10]	LIU Yubo, ZHANG Yan, WANG Liangmin, NING Kai, NIU Jun, ZAHNG Shifa. Multiple organ failure caused by tick bite: a case report [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(11): 681-682.
[11]	LIU Yunyi, ZHANG Jiawen, LIU Zijing, WANG Xiaoyan, LIU Yixuan, JIANG Peiyu, XU Yang. Update of the ceramide and related dermatosis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(10): 626-630.
[12]	YANG Yan, GUO Guizhen, WANG Weitao, MA Chunfeng. Effect of asiaticoside ointment on fibroblast and collagen expression in the keloid model of nude mice [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(7): 398-401.
[13]	YAO Likun. Clinical application of metformin in dermatology [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(7): 437-440.
[14]	JI Liyue, WANG Xiaohua, YANG Bin. Update of susceptibility genes of skin diseases related to diabetes [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(6): 374-377.
[15]	ZONG Xingyan, YANG Xiuhua, CHEN Hongquan. Protective effect of genistein on acute light damage induced by UVA in fibroblasts cells [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(5): 268-271.

The role of fibroblasts in skin diseases

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10