Abstract: Objective: To assess the HPV clearance and safety of photodynamic therapy using 5-aminolaevulinic acid for cervical high risk human papillomavirus (HR-HPV) infection. Method: Thirty-five patients with cervical HR-HPV infection were divided into topical photodynamic therapy using aminolevulinic acid (ALA-PDT) group （n=17）and control group (n=18). The treatment group were treated once a week for three weeks. Results: After three treatments, the clearance rates were 58.82% (10/17) and 5.6% (1/18) in the treatment group and control group, respectively, with a significant difference (P<0.05). The adverse effects in the treatment group included mild to moderate pain, edema, erosion, without any infection, ulcers, scarring or cervical malformations. Conclusion: ALA-PDT is a safe and effective treatment for cervical HR-HPV infection.

Key words: aminolevulinic acid, photodynamic therapy, human papillomavirus