Abstract: Objective: To assess the efficacy of fractional CO2 laser combined with clobetasol propionate in the treatment of hypertrophic scars. ]Methods: Sixty nine patients were randomly divided into the drug group (30 patients) and the combination group (39 patients). All the patients were topically treated with clobetasol propionate, once a day for 3 months and the patients in the combination group were treated with additional fractional CO2 laser, once every 30 days for 3 times. Results: The effective rate in the combination group was 100%, which was higher than that in the drug group (76.92%), with a significant difference (P<0.05). The adverse reaction in the combination group was 7.69%, which was lower than that in the drug group (13.33%), with a significant difference (P<0.05). Conclusion: The efficacy of fractional CO2 laser combined with clobetasol propionate ointment is more effective than clobetasol propionate ointment alone in the treatment of hypertrophic scars.

Key words: fractional laser, compound clobetasol propionate, hypertrophic scars