Abstract: Caspase-3 and Caspase-8 are important proteins in the process of apoptosis. Caspase-8 can start apoptotic reaction which can mediate apoptosis in a variety of ways. Caspase-3 can accelerate cell apoptosis after activation. The new studies reported high expression of Caspase-3, Caspase-8 in lichen planus lesions, especially in the basal layer which showed that Caspase-3, Caspase-8 might be involved in the apoptotic response process of lichen planus.

Key words: Caspase-3, Caspase-8, lichen planus, apoptosis