Abstract:

Objective: To determine the effect of total glucosides of paeony (TGP) on atopic dermatitis in mice.  Methods: An atopic dermatitis model was established on the back of NC/Nga mice with DNCB. Thirty mice were divided into 3 groups: control group, model group and TGP group (10 mice in each group). The mice of TGP group were treated by TGP for 14 days. The levels of serum cytokines including IL-4 and IL-5, IFN-γ and IgE were detected with ELISA kit at day 8th and 15th. Results: TGP could significantly decrease the skin thickness and weightness at 8 days and 15 days (P＜0.05). The levels of IL-4,IL-5 and IgE were significantly decreased , while the level of IFN-γ was increased in TGP group, compared with other groups. Conclusion: TGP has protective effects on atopic dermatitis in mice, which may be through inhibiting production of IgE, IL-4 and IL-5, and promoting the secretion of IFN-γ. 

Key words: total glucosides of paeony')">

total glucosides of paeony, atopic dermatitis, cytokines,   ')">mice