Abstract: Objective: To determine the correlation between the serum RPR titers and neurosyphilis. Methods: Three hundred and sixty patients with syphilis (120 with HIV) diagnosed from June 2013 to June 2016 were treated with lumbar puncture, CSF test and serum RPR titers test. Results: Sixty eight (28.33%) and 61(50.83%) patients were confirmed or suspected as having neurosyphilis in 240 patients with non-HIV infection and 180 patients with HIV infection respectively. The neurosyphilis positivity rates of the RPR titers 1∶1, 1∶2, 1∶4, 1∶8, 1∶16, 1∶32 in the patients with HIV-infection were 0%, 33.33%, 40%, 75%, 75% and 66.67% respectively, while in the patients with non-HIV infection the neurosyphilis positivity rates were 10%，15.38%，32.14%，35.71%，50% and 50% respectively. The syphilis positivity rate was linearly correlated with the serum RPR level in the patients (P<0.05). Conclusion: The neurosyphilis positivity rate was correlated with the serum RPR titer and the higher the serum titers level is, the higher the risk of neurosyphilis will be.

Key words:

RPR titers')">

RPR titers, neurosyphilis