China Journal of Leprosy and Skin Diseases ›› 2021, Vol. 37 ›› Issue (7): 419-423.doi: 10.12144/zgmfskin202107419

• Original Articles • Previous Articles     Next Articles

Analysis of albumin quotient and IgG index in 205 HIV-negative syphilis patients

GUO Ze1, TANG Huayang1, WANG Zaixing1, LIN Da1, LI Hui1, CHEN Yue2, ZHAO Xu2, YANG Sen1   

  1. 1 Department of Dermatology and Venereology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 2 Anhui Medical University, Hefei 230000, China
  • Online:2021-07-15 Published:2021-06-25
  • Contact: TANG Huayang, E-mail: tanghuayang@hotmail.com; LI Hui, E-mail: 723475415@qq.com

Abstract: Objective: To analyze the albumin quotient (QAlb) and IgG index in HIV-negative syphilis patients. Methods: 205 syphilis inpatients were collected including 124 non-neurosyphilis patients and 81 neurosyphilis patients. The sensitivity, specificity and diagnostic efficiency of  QAlb and IgG index was calculated use SPSS 25.0 software. Results: The QAlb and IgG index were (6.98±3.80) and (1.51±1.16) in the neurosyphilis patients which were higher than that in the non-neurosyphilis patients (4.63±2.03 and 0.67±0.48), with significant differences (P<0.001), the IgG index of the neurosyphilis patients was (2.14±1.31) in TRUST positive group, which was higher than that in negative group (1.10±0.84), with a significant difference (P<0.001). The sensitivity of QAlb and IgG index in the diagnosis of neurosyphilis was 73.33% and 59.60%, specificity was 66.29% and 79.25%, positive predictive value was 27.16% and 72.84%, negative predictive value was 93.55% and 67.74%, and the diagnostic efficiency was 67.32% and 69.76%, respectively. Conclusion: The QAlb and IgG index can be used for the auxiliary diagnosis of neurosyphilis.

Key words: syphilis, neurosyphilis, cerebrospinal fluid, QAlb, IgG index