Abstract: The data and specimens of 11,602 cases with venereal diseases in our hospital from 2015 to 2019 were analyzed retrospectively. The result showed the annual positivity rate of TPPA in these patients was significantly higher than that of RPR, with significant differences (Ps<0.05). There was no significant difference of the positivity rate of syphilis in female and male (P＞0.05). The positivity rate of syphilis increased in the order of rural areas, counties urban areas(Ps<0.05). The peak age of syphilis was from 20 to 50 years in these patients. The occupations with the highest incidence of syphilis was the migrant workers, followed by salesman and truck driver.

Key words: syphilis, epidemic characteristics, Shandong Province