Abstract: Objective: To investigate the incidence rate of syphilis in HIV-positive patients and the influencing factors on treatment outcome. Methods: The data of the patients with HIV-positive, whose syphilis related indicators were detected, in our hospital from 2012 to 2018 were collected, and the incidence rate of syphilis in these patients and the influencing factors on treatment outcome were analyzed. Results: The infection rate of syphilis was 25% in 480 HIV-positive patients. Logistic regression analysis showed that the risk factors for syphilis infection included age from 21 to 30, gay infection way, more than 2 sexual partners, unsafe injection history and no HAART treatment history. Cox regression analysis showed that influencing factors on treatment outcome of syphilis included more than 2 sexual partners, unsafe injection history, no HAART treatment history, CD4+T count, syphilis initial titer and select medication. Conclusion: The incidence rate of syphilis in HIV-positive patients is high and more than 2 sexual partners, unsafe injection history, no HAART treatment history, etc. are the influencing factors on treatment outcome of syphilis.

Key words: HIV, syphilis, risk factors