Abstract: Objective: To assess the efficacy of Mohs microgrphic surgery in the treatment of  extramammary Paget’s disease (EMPD). Methods: The lesions and skin around the lesions of  2cm were removed by Mohs micrographic surgery and the wounds were given skin graft after confirmed negativity for?tumor?cells. After the surgery, 31 patients were given photodynamic therapy, once a week for 4 times and 11 were given local imiquidod cream, once a day for 6 months. All the patients were followed up for 8-36 months. Results: Six patients relapsed and the recurrence rate was 14.3%. Out of the 6 patients, 4 were treated with photodynamic therapy and 2 were treated with local imiquidod cream after Mohs micrographic surgery. Conclusion: Mohs micrographic surgery combined with the photodynamic therapy or imiquimod cream is effective in the treatment of EMPD. 

Key words: extramammary Paget’s disease, photodynamic therapy, Mohs micrographic surgery, imiquimod