AP1S3基因突变与泛发性脓疱型银屑病的相关性研究

Abstract

Abstract: Objective: To identify the gene mutation of AP1S3 (encoding the s1C subunit of the AP-1 complex) in 107 cases with generalized pustular psoriasis (GPP) in Chinese Han populations. Methods: Genomic DNA was extracted from the peripheral blood. All the exons of AP1S3 were amplified by PCR. Sanger sequencing was performed to screen the mutations in AP1S3. Results: No mutation and single nucleotide polymorphism (SNP) in AP1S3 were detected in all GPP individuals. Conclusion: The mutation in AP1S3 gene is not associated with GPP in this group of patients.

Key words: generalized pustular psoriasis, AP1S3, gene mutation

LI Lulu, YOU Jiabao, FU Xian, YU Gongqi, LIU Hong, ZHANG Furen, . Association of AP1S3 mutation with generalized pustular psoriasis[J].China Journal of Leprosy and Skin Diseases, 2018, 34(3): 131-134.

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Association of AP1S3 mutation with generalized pustular psoriasis

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