Abstract: Objective: To access the efficacy of radiofrequency ablation on the lesions of cervical condyloma acuminatum after ALA-PDT treatment. Methods: The patients with cervical condyloma acuminatum after 3 times of ALA-PDT treatment were randomly divided into 2 groups. The study group was treated with radiofrequency ablation, while the control group was treated with ALA-PDT for 1 time. The cure rate, HPV negative conversion rate, the recurrence after 3 months and the satisfaction of the patients were assessed. Results: A total of 62 patients were included in the study, including 32 cases in the study group and 30 cases in the control group. The cure rates were 96.88% and 76.67% respectively, with a significant difference (χ2=5.627, P=0.024). The HPV negative conversion rates at 3 months were 84.38% and 60.00% respectively and the difference was significant (χ2=4.623, P=0.046). The patients satisfaction in the study group was 92.75%, which was higher than that in the control group (66.67%), with a significant difference (χ2=13.857, P=0.001). Conclusion: Radiofrequency ablation on the lesions of cervical condyloma acuminatum after ALA-PDT treatment has a high cure rate and high HPV negative conversion rate. 

Key words: condyloma acuminatum, cervix, radiofrequency ablation, interferon, ALA-PDT, human papilloma virus