Abstract: Objective: To investigate the correlation of body mass index (BMI), serum levels of IL-23, vaspin and RBP-4 with metabolic syndrome (MS) in patients with psoriasis. Methods: 120 patients with psoriasis vulgaris were divided into psoriasis combined with MS group and psoriasis alone group. The differences of BMI, IL-23, vaspin and RBP-4 between the two groups were compared, and the diagnostic value of BMI and above adipokines for the risk of MS were analyzed. Results: Compared with psoriasis group, the BMI, serum levels of vaspin and RBP-4 in psoriasis group combined with MS were increased, with statistical significance (P<0.05). In psoriasis patients, for every 1 kg/m2 increase of BMI, the risk of MS increased by 1.681 times (OR 1.681, 95% CI 1.330-2.125). For every 1 ng/mL decrease of vaspin, the risk of MS increased by 2.833 times (OR 0.353, 95% CI 0.160-0.780). For every 1 μg/L increase of RBP-4, the risk of MS in patients with psoriasis increased by 1.203 times (OR 1.203, 95% CI 1.011-1.431). There was no significant difference of IL-23 level between the two groups (P>0.05). Conclusion: BMI and serum vaspin and RBP-4 are the risk factors for MS in patients with psoriasis. According to the above indicators, the risk of MS in patients with psoriasis can be predicted and early targeted intervention measures can be taken to reduce the incidence of MS in patients with psoriasis.

Key words: psoriasis, metabolic syndrome, IL-23, vaspin, RBP-4