China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (12): 893-895.doi: 10.12144/zgmfskin202512893

• Case Reports • Previous Articles     Next Articles

Actinic prurigo successfully treated with tofacitinib: a case report

WEI Ting1,2,3, ZHANG Fan1,2, LIU Jianxin1,2, TIAN Hongqing1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China; 3 Tai'an City Central Hospital, Tai'an 271000, China
  • Online:2025-12-15 Published:2025-11-28

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Abstract: A 36-year-old female patient presented with recurrent erythema and papules on the face, neck, and retroauricular area accompanied with pruritis for 4 years. The ultraviolet light sensitivity test showed a UVA-MED value of 4.1 J/cm2, UVB-MED value of 48.6 mJ/cm2. Her serum IgE level was 1082 kU/L. The diagnosis of actinic prurigo was made. She was treated with oral tofacitinib 5 mg twice daily. Pruritus began to alleviate within 2 days, skin lesions started to improve after 1 week, and complete resolution of all lesions occurred within 2 weeks. No adverse reactions were reported, and no recurrence was observed during the 1-year follow-up period.

Key words: tofacitinib, actinic prurigo