Abstract: A 63-year-old male presented with generalized erythema and desquamation for 2 months. Physical examination showed widespread erythema and scales on his whole body, with multiple grouped follicular keratotic papules on his trunk. The histopathological features of the skin lesion were consistent with those of pityriasis rubra pilaris. The patient was initially treated with oral acitretin combined with subcutaneous injections of secukinumab for 5 weeks, however, the disease was not improved. So, a combined treatment of oral tofacitinib and acitretin was used. After 4 weeks, a significant improvement was observed. There was mild recurrence of skin lesions after the dosage reduction of tofacitinib and acitretin at the 8-month follow-up.

Key words: pityriasis rubra pilaris, tofacitinib, acitretin