China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (3): 180-183.doi: 10.12144/zgmfskin202503180

• Original Articles • Previous Articles     Next Articles

Hailey-Hailey disease successfully treated with apremilast: two cases report and literature review

LIU Wenhui1,2, CHEN Shengli1,2, SHI Zhongxiang1,2, LIU Hong1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2025-03-15 Published:2025-03-03

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Abstract: Hailey-Hailey disease is a inheritary disease and there is currently no unified treatment standard. Apremilast, an oral small molecule phosphodiesterase 4 (PDE 4) inhibitor, can significantly improve Hailey-Hailey disease according to foreign reports, but there are no relevant reports in China. This paper reported two patients with Hailey-Hailey disease who had a good response to apremilast in China reported for the first time, and relevant literature was reviewed.

Key words: apremilast, acitretin, Hailey-Hailey disease (HHD), PDE4