China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (6): 461-465.doi: 10.12144/zgmfskin202506461

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Update of periostin in the mechanism of keloid formation

HUANG Chuhan1,2,4, HE Zhihong1,3,4, ZHONG Shiyi1,2,4, WANG Zhihan1,2,4, CHEN Huisong1,2,4, YANG Dingquan2,4, LIU Qingwu2,4   

  1. 1 Beijing University of Traditional Chinese Medicine, Beijing 100029, China; 2 Department of Dermatology, China-Japan Friendship Hospital, Beijing 100029, China; 3 Department of Dermatology, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China; 4 National Center for Integrated Traditional Chinese and Western Medicine, Beijing 100029, China
  • Online:2025-06-15 Published:2025-05-23

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Abstract: Periostin is an extracellular matrix protein that interacts with cells through various integrins and participates in a variety of pro-fibrotic processes, playing an important role in the normal wound healing process and abnormal scar hyperplasia at the stage of proliferation and remodeling. This paper reviews the basic features and functions of periostin and its relationship with keloid formation.

Key words: periostin, keloids, formation mechanism