Abstract: Umbilical cord mesenchymal stem cells (UCMSCs) have great potential in the field of skin regeneration and wound healing due to their multipotent differentiation capacity, immune regulatory ability, and abundant secretion of exosomes. UCMSCs participate in all stages of wound healing, including hemostasis, inflammation, proliferation, and remodeling, through the secretion of exosomes. UCMSCs have been successfully applied in the treatment of acute trauma, burns, chronic wounds, and skin aging, showing good efficacy and safety. This paper elaborates on the mechanisms of UCMSCs promoting skin healing and their applications in clinical practice.

Key words: mesenchymal stem cells, skin regeneration, wound healing