Abstract: Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases, and its carcinogenic effect has been extensively studied. The models established for the treatment of HPV infection mainly include two-dimensional cell models, three-dimensional organoid models, rabbit models, mouse models, etc. Due to the high host specificity of HPV, traditional models are difficult to simulate the dynamic virus-host interaction, and a genotype-specific modeling system has not yet been established. This review provides a systematic review of the existing modeling systems for HPV infection.

Key words: HPV, cellular models, organoid, animal model