China Journal of Leprosy and Skin Diseases ›› 2026, Vol. 42 ›› Issue (6): 403-407.doi: 10.12144/zgmfskin202606403

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Efficacy of long-pulse 1064 nm Nd:YAG laser combined with topical 2% carteolol hydrochloride ophthalmic solution in the treatment of infantile hemangioma

SUN Lina1, ZHANG Jingjie1, YUAN Xiangfeng1, PANG Yunyan1, LIU Guoyan2,3   

  1. 1 Affiliated Hospital of Shandong Second Medical University, Weifang 261000, China; 2 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 3 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2026-06-15 Published:2026-06-04

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Abstract: Objective: To assess the efficacy and safety of longpulse 1064 nm Nd:YAG laser combined with topical 2% carteolol hydrochloride ophthalmic solution in the treatment of lowtomoderate risk superficial proliferative infantile hemangiomas (IH). Methods: A retrospective analysis was performed on 98 children with lowtomoderate risk superficial proliferative IH treated in the Department of Dermatology, the Affiliated Hospital of Shandong Second Medical University. According to the treatment regimen, they were divided into the laser group (treated with longpulse 1064 nm Nd:YAG laser alone, n = 48) and the combination group (treated with longpulse 1064 nm Nd:YAG laser plus topical 2% carteolol hydrochloride ophthalmic solution, n = 50). The effective rate, marked effective rate, number of laser treatments, and incidence of adverse reactions were compared between the two groups. The chisquare test or Fisher's exact test was used for comparison of enumeration data between groups. Results: The effective rate and marked effective rate of the combination group were 90.0% and 76.0%, respectively, which were significantly higher than those of the laser group (83.3% and 58.3%, respectively), with statistically significant differences (both P＜0.05). The number of laser treatments in the combination group was (2.63 ± 0.97) times, which was significantly less than that in the laser group ［(4.25 ± 1.07) times］, and the difference was statistically significant (P＜0.01). Additionally, the incidence of adverse reactions in the combination group was 12%, which was significantly lower than that in the laser group (29%), with a statistically significant difference (P＜0.001). Conclusion: Topical 2% carteolol hydrochloride ophthalmic solution can enhance the efficacy of long-pulsed 1064 nm Nd:YAG laser in the treatment of low- to intermediate-risk superficial proliferative IH, reduce the number of laser treatment sessions, and decrease the incidence of adverse reactions.

Key words: infantile hemangioma, beta-blocker, 2% carteolol hydrochloride ophthalmic solution, long pulse 1064 nm Nd:YAG laser