Abstract: Glucocorticoids and immunosuppressants are the main treatment modalities for bullous pemphigoid (BP). However, long-term use of these drugs can cause serious side effects, and the recurrence rate remains high. With the research on disease-modifying of BP, the targeted therapy of BP has received great attention, the more and more new drugs have been applied in clinic. Based on the relevant research on disease modification of BP, this paper reviews the current research progress of new target drugs of BP. 

Key words: bullous pemphigoid, target therapy, disease-modifying, therapeutic mechanism, small molecule inhibitors